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Cervical Spine • 100mg Active
Shoulder / Rotator • Synovial Comfort
Elbow Tendon • Cryo-Absorption
Carpal Fascia • Rapid Transdermal
Lumbar Spine • 150mg Relief
Knee Joint • 10-Minute Comfort
Ankle & Achilles • Quick Cooling
10,000 MG (CBG 5% | CBD 5%)

A breakthrough in topical cannabinoids

Pharmaceutical-grade CBG and CBD transdermal matrix engineered for deep-tissue joint and muscular comfort within 15 minutes.

0.0% THC Non-Drowsy
Liposomal Delivery
ISO 17025 Certified
2.AG Topical Cannabinoid Complex Pump Bottle
10,000 MG
Topical Cannabinoid Complex
Transdermal Liposomal Emulsion • 100 mL
★★★★★
VERIFIED REVIEWS
"BETTER THAN I EXPECTED" — JOHN S.
•
"GREAT FOR POST-TRAINING SORENESS" — SHAINA T.
•
"I WAS BLOWN AWAY BY THE SPEED" — LARRY W.
•
"THIS CREAM IS AMAZING FOR MY KNEES" — WHITNEY B.
•
"GAMECHANGER FOR MORNING MOBILITY" — DR. MARCUS R.
•
"ZERO STICKY RESIDUE, INSTANT COOLING" — ELENA V.
•
"FINALLY A REAL CLINICAL FORMULATION" — DAVID P.
•
"BETTER THAN I EXPECTED" — JOHN S.
•
"GREAT FOR POST-TRAINING SORENESS" — SHAINA T.
•
"I WAS BLOWN AWAY BY THE SPEED" — LARRY W.
•
"THIS CREAM IS AMAZING FOR MY KNEES" — WHITNEY B.
•
"GAMECHANGER FOR MORNING MOBILITY" — DR. MARCUS R.
•
"ZERO STICKY RESIDUE, INSTANT COOLING" — ELENA V.

Rapid Relief Cream: Clinical Proof Points

Formulated to transcend conventional balms through pharmaceutical-grade cannabinoid isolate standards and cutaneous cellular permeability.

93 %
15-Min Fast Acting Onset

93% of patients in double-blind trial reported significant joint and muscular comfort within 15 minutes of initial cutaneous application.

99.4 %
Bioactive Purity Matrix

Supercritical CO2 extracted CBG and CBD isolate matrix refined to 99.4% purity, encapsulated in phospholipid nano-liposomes.

0.0 %
Zero Psychoactive Residue

Triple-tested with non-detectable THC levels (<0.001%). Non-drowsy, zero drug-test interference, and clean water-based dermal absorption.

TOPICAL CANNABINOID COMPLEX

Rapid Relief Cream

★★★★★
4.9 / 5.0 (487 Verified Clinical Reviews)

A clinical-strength transdermal emulsion delivering equal ratios of pharmaceutical-grade Cannabigerol (CBG) and Cannabidiol (CBD). Formulated with nano-liposomes to penetrate deep articular and muscular tissue without greasy residue.

MOST PRESCRIBED
10,000 MG
CBG 5% | CBD 5%
$88.00
5,000 MG
CBG 2.5% | CBD 2.5%
$54.00
2,500 MG
CBG 1.25% | CBD 1.25%
$34.00
Clinical Refill Protocol SAVE 20%
Delivered fresh every 30 days • Pause or cancel anytime
$70.40
One-Time Order Single 100 mL clinical pump bottle
$88.00
In Stock — Dispatched within 24h from FDA-registered cGMP facility
2 Bioactive Cannabinoids 5,000mg CBG (Cannabigerol) + 5,000mg CBD (Cannabidiol) pure pharmaceutical isolate.
5 Targeted Botanical Actives Arnica Montana, Boswellia Serrata, Cryo-Menthol USP, Natural Camphor, and Eucalyptus Globulus.
Transdermal Liposomal Delivery Phospholipid vesicles facilitate 4.8x faster cutaneous uptake across the stratum corneum barrier.
Zero Residue & 0.0% THC Quick-drying clinical emulsion leaves skin matte, breathable, and completely non-greasy.
FORMULATION REGISTRY

The Apothecary Ledger

Each compound in 2.AG is selected for its distinct molecular pharmacology and paired in precise stoichiometric ratio.

COMPOUND #01 PRIMARY ACTIVE

Cannabigerol (CBG)

"The Stem Cell Cannabinoid" • 5.0% w/w

The precursor from which all cannabinoids synthesize. Directly interacts with peripheral CB2 receptors and TRPA1 ion channels to downregulate localized inflammatory cascades without desensitization.

Molecular Weight 316.48 g/mol
Target Receptor CB2 / TRPA1 / α2
COMPOUND #02 PRIMARY ACTIVE

Cannabidiol (CBD)

"Phytocannabinoid Modulator" • 5.0% w/w

Supercritical isolate providing allosteric modulation of TRPV1 vanilloid receptors. Works in stoichiometric synergy with CBG to alleviate deep-set musculoskeletal tension and articular friction.

Molecular Weight 314.46 g/mol
Target Receptor TRPV1 / 5-HT1A
COMPOUND #03 BOTANICAL

Arnica Montana Extract

"Sesquiterpene Lactone Complex"

Wild-harvested mountain arnica concentrated for helenalin. Accelerates local micro-circulatory flow, aiding the clearance of lactic acid and metabolic bi-products in strained muscle fibers.

Active Biomarker Helenalin > 1.2%
Clinical Action Micro-Vascular Flow
COMPOUND #04 BOTANICAL

Boswellia Serrata Resin

"Frankincense Acid Matrix" (65% AKBA)

Standardized for acetyl-11-keto-β-boswellic acid (AKBA), a potent natural inhibitor of 5-lipoxygenase (5-LOX). Preserves joint cartilage integrity and supports fluid articular flexion.

Enzymatic Target 5-LOX Inhibition
Standardization 65% Boswellic Acids
COMPOUND #05 THERMAL SENSORY

Cryo-Menthol USP & Camphor

"TRPM8 Sensory Thermoreceptors"

Natural crystal menthol and camphor deliver immediate cooling sensation within 90 seconds. Engages cold-sensitive cutaneous fibers to intercept nociceptive signaling while cannabinoids penetrate.

Sensory Onset < 90 Seconds
Grade Standard United States Pharma
COMPOUND #06 TRANSDERMAL SYSTEM

Phospholipid Liposomes

"Sub-Micron Lipid Spheres" (85 nm)

Engineered vesicles mimicking human cell membranes. Encapsulates hydrophobic cannabinoids to transport them directly across the stratum corneum into deeper synovial and muscular tissue.

Mean Diameter 85 Nanometers
Bio-Permeance 4.8x Enhanced
APPLICATION PROTOCOL

Prescriptive Dosage & Target Mapping

Precise application maximizes cutaneous receptor binding. Follow the clinical protocol below or select your anatomical focus area.

STEP 01

Metered Dose Dispensing

Depress the vacuum pump 1 to 2 times directly into palm or affected skin. Each full depression dispenses exactly 50mg of bioactive cannabinoid complex.

STEP 02

Transdermal Effleurage

Massage firmly using small circular strokes for 30–45 seconds. The water-based lipid emulsion rapidly sinks into epidermal layers without staining clothing.

STEP 03

Bi-Phasic Receptor Binding

Cryo-cooling activates in under 90 seconds. Cannabinoid deep-tissue receptor binding peaks between 12 to 15 minutes and maintains steady comfort for 4–6 hours.

Select Anatomical Target:

Cervical Spine & Trapezius

100 MG ACTIVE (2 PUMPS)

Apply directly across the sub-occipital margin and along the lateral trapezius. Massage with upward bilateral effleurage until the lipid emulsion fully permeates the cutaneous barrier.

Metered Volume 2 Metered Pumps
Recommended Frequency 2-3x Daily
Onset Window 8-12 Minutes
PATIENT TESTIMONIALS

Verified Clinical Evidence

Documented outcomes from patients, physicians, and athletic recovery practitioners.

★★★★★

"Better than anything my rheumatologist recommended."

I’ve tried prescription topical NSAIDs and standard CBD creams for my knee osteoarthritis. 2.AG is on another level entirely. The addition of CBG makes a visible difference in morning flexion.

★★★★★

"Cuts rotator cuff recovery time by half."

As a competitive swimmer logging 20km weekly, shoulder inflammation used to sideline me every taper week. Two pumps before sleep and my joint capsular soreness is completely gone by morning.

VIDEO CASE STUDY

Dr. Marcus R., MD

Orthopedic Sports Medicine Physician on 2.AG in clinical practice

★★★★★

"Finally relief for my chronic lumbar stiffness."

Sitting at my desk for 10 hours ruined my lower back. The cooling sensation happens right away, and after about 10 minutes I can feel the deep muscular knot unclenching. Zero greasy residue on shirts.

TRANSPARENT APOTHECARY

Verify Your Batch Testing Report

Every production lot undergoes third-party ISO/IEC 17025 accredited laboratory testing. Verify potency, solvent purity, and 0.0% THC compliance by entering your bottle’s bottom stamp.

Sample Production Runs:
LAB REPORT ID
2AG-9042
100% PASSED
Batch Tested: OCT 2026 • ProVerde Laboratories ISO/IEC 17025 Accredited
Analytic Compound Claim Lab Result Status
Cannabigerol (CBG) 5,000 mg 5.04% (Target 5.0%) PASS
Cannabidiol (CBD) 5,000 mg 5.08% (Target 5.0%) PASS
Delta-9 THC 0.00% <0.001% (ND) PASS
Heavy Metals (Pb, As, Cd, Hg) None Non-Detected (ND) PASS
Pesticides & Residual Solvents None Non-Detected (ND) PASS
KNOWLEDGE BASE

Frequently Asked Questions

Scientific answers regarding formulation, legality, drug testing, and protocol.

Cannabigerol (CBG) is the chemical precursor to all major phytocannabinoids. It binds directly with peripheral CB2 receptors and TRPA1 ion channels, whereas standard CBD operates primarily as an allosteric modulator. In combination at a 1:1 ratio, they provide synergistic bi-phasic receptor modulation that is significantly more effective than single-isolate formulas.
No. 2.AG is formulated exclusively with pharmaceutical-grade, pure CBG and CBD isolates, triple-tested down to parts-per-billion with 0.0% THC (Non-Detected). Standard workplace and athletic drug tests screen specifically for THC metabolites (THC-COOH), which are completely absent from 2.AG.
2.AG works through a bi-phasic activation process: The USP cryo-menthol and botanical camphor stimulate TRPM8 cold-sensing receptors within 90 seconds, providing immediate sensory comfort. Concurrently, the phospholipid nano-liposomes penetrate the stratum corneum, enabling CBG and CBD to reach joint synovial receptors within 10 to 15 minutes.
Unlike traditional wax-heavy salves and coconut oil balms, 2.AG is formulated as a light, water-based transdermal emulsion. It absorbs completely within 45 seconds, leaving the skin matte, hydrated, and dry to the touch with zero transfer to clothing or bedsheets.
Yes. 2.AG is classified as an over-the-counter clinical topical musculoskeletal comfort formulation. You can use your HSA or FSA card directly at checkout or submit your itemized invoice for standard reimbursement.
We offer an unconditional 60-Day Patient Comfort Guarantee. If 2.AG does not provide the joint and muscular relief you require, simply contact our clinical care desk for a 100% full refund with no return shipping required.
Clinical Bag
Free Priority Shipping at $100 $70 / $100
Recommended Clinical Add-On:
Travel Sachet (500mg) Pocket-sized single dose • $9.00